GLI3 and endometriosis: Four of the genes harboring digit ratio SNPs (EFNA1, HOXD12/HOXD11, GLI3 and SALL1) show evidence of altered expression in endometriosis; one digit ratio SNP is in the gene TOX3, which is genome-wide significant for risk of PCOS [83], two SNPs are in genes (SMOC1 and HOXA12) that regulate gonad development, and an interaction of HOXA12 with GLI3 mediates development of the vagina and uterus.