Compared to the minor (lower frequency) haplotype, the major FSHB haplotype has been associated across a large set of studies with higher FSH and lower LH (accounting for 3.5% and 7.1% of their variation respectively, in a typical population), higher risk of endometriosis, a large suite of endometriosis-associated and other traits, and lower risk of PCOS [72–79] (Table 2). This evidence concerns the gene PLOD1 and endometriosis.