Next generation sequencing (NGS) (Table 1) revealed presence of heterozygous LAMB1 (encodes for laminin subunit beta-1 protein) and MPDZ gene (encodes for Multiple PDZ domain protein) mutation from paternal side whereas that of GAA gene (encodes for acid alpha-glucosidase also known as acid maltase synthesized in lysosomes) mutation from maternal side (gene associated with congenital hydrocephalus). The gene discussed is MPDZ; the disease is congenital hydrocephalus.