Associations among P53 and RB genes mutations, estrogen and progesterone receptor expression, and HPV positive cases among the study groups: P53 and RB gene mutations were detected in six and three HPV positive BC cases, respectively, which was statistically insignificant with p-value = 0.089 for P53 and 0.568 for RB gene mutations. This evidence concerns the gene RB1 and breast cancer.