APAF1 and central nervous system cancer: In addition, we found that in glioma tissues from the TCGA database, SAA1 levels were associated with a range of anti-apoptotic genes (Bcl-xl, BFL1, MCL1, BIRC5, and Fas) and pro-apoptotic genes (Bim, Bid, CASP9 and Apaf1) (Fig. 2B).