On the other hand, we noted that the diagnostic efficiency of the autoantibody panel comprising BMI-1, HSP70, NY-ESO-1 and p53 autoantibodies for early stage breast cancer was similar with other optimized autoantibody panels identified for early stage esophagogastric junction adenocarcinoma and esophageal squamous cell carcinoma 16, 17. The gene discussed is TP53; the disease is breast cancer.