To further investigate whether the regulation of LINC01296 on the migration and invasion of SW480 and A549 cells depends on miR-141-3p, and to further verify that LINC01296 can regulate the expression of ZEB1/ZEB2 by targeting miR-141-3p in tumor cells, first we co-transfect si-LINC01296 and miR-141-3p inhibitor (inhibitor-miR-141-3p) into SW480 and A549 cell lines and verify cell migration and invasion by transwell analysis. Here, ZEB1 is linked to neoplasm.