For instance, survival-related lncRNAs SNHG12 and MINCR were epigenetically activated in multiple cancer types, including breast, bladder, endometrial, colorectal, and lung cancer 23; EPIC1 was epigenetically activated and correlated with poor survival in breast cancer 24; DNA-methylation-mediated activating of lncRNA SNHG12 promoted temozolomide resistance in glioblastoma 25. This evidence concerns the gene EPIC1 and breast carcinoma.