FGD5 and esophageal squamous cell carcinoma: Moreover, increased FGD5-AS1 expression manifested a close association with tumor size, TNM stage, and lymph node metastasis in esophageal squamous cell carcinoma 30; FGD5-AS1 may promote NSCLC cell proliferation 29; FGD5-AS1 knockdown inhibited colorectal cancer cell proliferation, migration, and invasion, and promoted cell apoptosis 27.