By investigating the prognostic events of nine LGALS family members in patients with ovarian cancer, we found that elevated levels of LGALS4, LGALS8, LGALS10 and LGALS13 were related to a better OS in total patients with ovarian cancer, LGALS1 level was associated with a worse OS in total patients with ovarian cancer, and LGALS2, LGALS3, LGALS12 and LGALS14 had no significant prognostic influence on total patients with ovarian cancer. Here, LGALS8 is linked to ovarian cancer.