By investigating the prognostic events of nine LGALS family members in patients with ovarian cancer, we found that elevated levels of LGALS4, LGALS8, LGALS10 and LGALS13 were related to a better OS in total patients with ovarian cancer, LGALS1 level was associated with a worse OS in total patients with ovarian cancer, and LGALS2, LGALS3, LGALS12 and LGALS14 had no significant prognostic influence on total patients with ovarian cancer. The gene discussed is LGALS4; the disease is ovarian cancer.