In addition, by Western blot analysis of ESCC cells, compared with the NC group, the knockdown group showed downregulated circ_0000700 expression; significantly elevated Caspase-3, Caspase-9, Bax, and E-cadherin protein expression levels; and reduced Bcl-2, vimentin, and N-cadherin protein expression levels (Figure 3D). The gene discussed is CDH2; the disease is esophageal squamous cell carcinoma.