For instance, Xu et al. showed that circ_0000654 facilitates ESCC cell proliferation, migration, invasion, and apoptosis in vitro by sponging miR-149-5p 10, and Huang et al. reported that the upregulation of circular RNA ciRS-7 expression enhances the migration and invasion of ESCC cells by affecting miR-7/KLF4 and NF-κB signaling 11. Here, NFKB1 is linked to esophageal squamous cell carcinoma.