In the L02 human liver cell line, the stable ectopic expression of the PIM2 gene induces malignant transformations 51, and knockdown of PIM2 in liver cancer results in potent anti-proliferative effects on cell growth G0/G1 cell-cycle blockade and the down-regulation of S phase and G2/M phase genes 52. This evidence concerns the gene PIM2 and liver cancer.