CDH2 and hepatocellular carcinoma: For example, after treatment with exosomes derived from HCC cells, the expression of EMT promoters (ZEB1, ZEB2, and Slug) and interstitial related markers (N-Cadherin, α-SMA and Vimentin) in liver cancer cells increased , While the expression of the promoter (OVOL1) driven by epithelial markers (E-cadherin) and mesenchymal-epithelial transition (MET) was reduced 56.