Wang et al. suggested that circPTGR1 could promote migration and metastasis in HCC through a circPTGR1/miR-449a/MET pathway 46, while miR-449a was described as having roles in cell differentiation and tumor suppression, as well as involvement in the inhibition of tumor growth and metastasis in HCC 47. This evidence concerns the gene MET and hepatocellular carcinoma.