Using Huh7 cells in vitro to simulate the insufficient radiofrequency ablation (RFA), the researcher found that exosomal lncRNA ASMTL-AS1 activated miR-342-3p/NLK/YAP signals, aggravating residual malignant hepatocellular carcinoma when RFA was insufficient, opening up a new way for the treatment of HCC and preventing its recurrence 42. The gene discussed is NLK; the disease is hepatocellular carcinoma.