The study by Yang et al. found that tumor-derived exosomal miR-92a-3p increased the expression of mesenchymal biomarkers (N-cadherin, β-catenin and Snail) by regulating the PTEN/AKT pathway, and at the same time decreased the protein level of E-cadherin, which promotes the EMT process and plays a key role in the metastasis of HCC 58. This evidence concerns the gene PTEN and hepatocellular carcinoma.