HLA-G and neoplasm: Thus, if patients showed suspicious clinical signs of transformation, such as rapidly increasing tumor mass or rising serum LDH, a thorough evaluation for transformation and appropriate subsequent management should be carried out, especially in patients with the aforementioned high risk of transformation (i.e., hemoglobin < 12 g/dL, increased LDH, elevated β2-microglobulin, and high FLIPI score at diagnosis).