In addition, Cells that migrated or invaded through the transwell chamber were also decreased in the CXCR-4-silenced cells upon pDC-CM treatment (P < 0.01; Figure 4E, F; Supplemental Fig. 1E, F), suggesting that CXCR-4 may play an important role in pDC-mediated cancer cell proliferation, migration and invasion. Here, CXCR4 is linked to cancer.