Moreover, wound healing and transwell assays revealed that the migration and invasion capability of oral cancer cells treated with different concentrations of pDC-CM increased remarkably in comparison with that of untreated oral cancer cells (P < 0.01; Figure 2B, 2D), suggesting that tumor-infiltrating pDC have the ability to promote cancer cell proliferation, migration and invasion in vitro. This evidence concerns the gene PDC and lip and oral cavity carcinoma.