Importantly, we also demonstrated that pDC-CM could significantly promote OSCC proliferation and migration via increasing CXCR4 expression in vitro, as reflected by the colony formation and transwell assays, suggesting that tumor-infiltrating pDC may contribute to the overexpression of CXCR-4, and subsequent growth and metastasis in oral cancer. The gene discussed is PDC; the disease is lip and oral cavity carcinoma.