Furthermore, SGC7901 cells co-cultured with CAFs for 24 hours expressed markedly lower levels of the epithelial marker E-cadherin and high levels of the mesenchymal N-cadherin and Vimentin (Figure 3D), indicating that CXCL12 secretion by fibroblasts enhanced the EMT of GC cells. This evidence concerns the gene CXCL12 and gastric cancer.