We identified seven genes with different mutation frequency between 10 DPHCC, 10 CK19+HCC, and 14 CK19-HCC, as well as commonly known hepatocellular carcinoma driver genes (TP53, TRET, CTNNB1) and related molecules involved in the PI3K-Akt signaling pathway. The gene discussed is KRT19; the disease is hepatocellular carcinoma.