Surprisingly, CK19+HCC differentially up-regulated genes were also mainly enriched in cancer-related pathways, such as NF-kappa B signaling pathway (hsa04064), PI3K-Akt signaling pathway (hsa04151), Wnt signaling pathway (hsa04310), etc. (Figure 4I). The gene discussed is AKT1; the disease is hepatocellular carcinoma.