PEAK1 and neoplasm: We found that TADA3 and PEAK1 mutations were significantly associated with advanced tumor stage (P = 0.048 and P = 0.048), INPP5D mutations were significantly associated with microvascular invasion (MVI) (P = 0.031), and GOLM1 mutations were significantly associated with advanced tumor stage and Distant metastasis (P = 0.003 and P = 0.031, respectively) (Figure 3C).