The pathological diagnosis of DPHCC is: (1) Immunohistochemically, more than 15% of the tumor cells, at least one hepatocyte marker (such as Hep Par 1) shows strong positive expression, and mainly diffuse distribution; (2) More than 15% of tumor cells, at least one cholangiocyte marker (such as CK19), and at least one hepatocyte marker (such as Hep par 1) are co-expressed. The gene discussed is KRT19; the disease is neoplasm.