The expression of LAG3, CTLA4, HAVCR2, PD-1, and PD-L1 were not markedly positive correlated with CENPF (Figure 11B, all R<0.75), and there was no significant correlation between the expression of these five genes and the overall survival rate in HCC patients (Figure 11C, all P>0.05). The gene discussed is CD274; the disease is hepatocellular carcinoma.