For subgroup survival analyses, upregulation of CENPF was significantly associated with poor OS in HCC patients with neoplasm histologic grade I and grade III (HR = 5.84, log rank P = 0.00064 and HR = 2.46, log rank P = 0.0041, respectively, Figures 6A and C), while no significant difference was found in HCC cases with grade II (HR = 1.49, log rank P > 0.05, Figure 6B). The gene discussed is CENPF; the disease is neoplasm.