(Figure 9B) By screening the correlation, expression data and prognosis information of these nine genes and E2F1, we found that CDK1 and E2F1 were evidently upregulated in HCC (Figure 9D, all P<0.05) compared with normal tissues, and significantly positively correlated with the expression of CENPF (Figure 9C, all P<0.01). The gene discussed is E2F1; the disease is hepatocellular carcinoma.