KRAS and cancer: Over expression of ADPRH was associated with several immune- and cancer-related processes and pathways including IL6/JAK-STAT3 signaling pathway, mTORC1 signaling pathway, P53 signaling pathway, KRAS signaling pathway, angiogenesis, epithelial-mesenchymal transition (EMT) and TNF-beta signaling pathway, demonstrating ADPRH in all possibility involved in the facilitation of cancer proliferation and immunosuppression (Figure 3A-J).