In the current work, our single‐center study of a lung cancer biomarker panel found that 4 biomarkers in combination, including pro-surfactant protein B (Pro-SFTPB) 22, 23, carbohydrate antigen 125 (CA125) 11, Cyfra21-1 14, and CEA 13, can dramatically improve the accuracy and sensitivity of lung cancer diagnosis. The gene discussed is SFTPB; the disease is lung carcinoma.