These findings imply that hypoxia decreases cellular levels of miR-1305 via the exosome-mediated export of miR-1305, leading to increased expression of cellular IGF1, MDM2 and FGF2. Consistent with a pro-tumor effect of exosome-mediated export of tumor-suppressive miR-1305, the aforementioned study also showed that patients with high exosomal let-7 had better survival rates than patients with low exosomal let-7 35. This evidence concerns the gene FGF2 and neoplasm.