It is revealed that FZYLF significantly inhibits the invasion and metastasis of the multidrug-resistant breast cancer cells MDA-MB-231/Adr and the mechanism of action may be related to its inhibition of the abnormal protein expression of WAVE3 gene, MMP-9, p-IκBα, and NF-κB (p65). The gene discussed is WASF3; the disease is breast cancer.