MMP9 and neoplasm: The NF-κB pathway is an important mechanism in WAVE3-mediated cell migration, and Teng et al. [27] have found out that WAVE3 gene knockout in breast cancer cells can lead to decease in MMP-9 and inhibit the activation and nuclear transport of NF-κB. The expression of WAVE3 is positively correlated with the extent of tumor invasion and progression and negatively correlated with clinic pathological parameters of tumor [6].