NOTCH1 and lip and oral cavity carcinoma: The statistical comparison between four subtypes of oral cancer relative to the immunoexpression of Notch1 showed no significant difference (p = 0.555; Table 1), a result supported by several other studies [18, 20, 23, 28], whereas Gan et al. and Ravindran and Devaraj observed a statistically significant difference when comparing the immunoexpression of Notch1 in OSCCs with different degrees of cell differentiation [24, 27].