MSTN and Duchenne muscular dystrophy: In contrast, several placebo-controlled clinical trials using myostatin inhibitors have failed to provide functional improvements in 6MWT and muscle masses in patients with DMD and inclusion body myositis, thus begging the question: whether improvements to murine musculature with myostatin inhibition translates to humans (Hanna et al., 2019; Polkey et al., 2019; Wagner, 2020).