PSMB8 and lobular neoplasia: In addition, although the blue module was not enriched in IgAN (FDR-corrected P > 0.05), PSMB8 and PSMB9, which were the hub genes in blue module, were identified as an IgAN susceptibility loci in an IgAN GWAS (Kiryluk et al., 2012), suggesting blue module might be associated with renal susceptibility in both IgAN and LN.