Overexpression of EZH2 increased the expression of miR-375 while it reduced the expression of FOXO1, and downregulation of miR-375 led to an increase in the expression of FOXO1 in BC cells (Figure 5F), indicating FOXO1 suppression is possibly implicated in EZH2/miR-375-mediated events in BC cells. The gene discussed is FOXO1; the disease is breast cancer.