For example, disease-specific antigen peptides fused to anti-DEC205 mAbs or single chain variable fragments (scFv) are targeted to steady state cross-presenting CD8+ conventional DCs and CD103+ migratory DCs (118), and suppressed murine models of CD4+ T cell-driven cartilage proteoglycan induced arthritis, DTH, T1D, and EAE as well as CD8+ T cell-driven contact hypersensitivity and T1D (138–142). This evidence concerns the gene CD4 and type 1 diabetes mellitus.