EAE is a CD4+ T cell driven CNS-specific autoimmune disease that involves complex immune responses and numerous neuroantigen targets including myelin oligodendrocyte glycoprotein (MOG), myelin basic protein (MBP) and proteolipid protein (PLP), that can mimic some of the complexities of human autoimmune diseases but with limitations. This evidence concerns the gene MBP and autoimmune disease.