This showed that the most prominent pathways activated the liver of these mutants are the pathways activated in autoimmunity (systemic lupus erythematosus), immune response to infection with an RNA virus (i.e., Coronavirus Pathogenesis Pathway), NF-kB and the interferon response (Figures 4C–E) among the most significantly enriched in the upregulated genes. The gene discussed is NFKB1; the disease is infection.