The finding that the pathway activated by SARS-CoV2, an RNA virus which induces a distinct set of genes in the airway epithelial cells in infected patients (48) had significant overlap with the genes activated in uhrf1 and dnmt1 mutant livers (Supplementary Figure 7C) indicates that loss of DNA methylation induces an immune response similar to infection with an RNA virus (Figure 4C, Supplementary Figure 7C). Here, UHRF1 is linked to infection.