INS and COVID-19: Therefore, in view of the excellent suggestion of TRIM induced by β-glucans as an “an efficient, low-cost and safe way” in a long term prophylactic setting applicable to different age groups of people and those with vacuous co-existing disease conditions in the defense against COVID-19 by Geller and Yan (1), we wish to reiterate that the metabolic effects of the β-glucans in terms of normalization of glucose levels, lipid levels and increase of insulin sensitivity significantly contributes to augment the TRIM response.