Although Basu et al.’ study reported an enhanced IFN-γ and IL-2 production and migratory responses induced by VEGF-A in human CD45RO+ CD4+ memory T-cells (47), there are growing evidences to support the immunosuppressive role of VEGF-A/VEGFR in T-cells (5) especially on tumor-induced T-cell exhaustion (44, 48). This evidence concerns the gene CD4 and neoplasm.