INS and polycystic ovary syndrome: In the first study cohort, including women with oligomenorrhea and/or hirsutism and enriched in PCOS patients, the assessment of metabolic parameters confirmed that SHBG <33.4 nmol/L identifies patients with adverse metabolic profile, including worse blood pressure, BMI, waist circumference, body composition (increased fat mass and reduced fat free mass), insulin, triglycerides and HDL cholesterol.