In the first study cohort, including women with oligomenorrhea and/or hirsutism and enriched in PCOS patients, the assessment of metabolic parameters confirmed that SHBG <33.4 nmol/L identifies patients with adverse metabolic profile, including worse blood pressure, BMI, waist circumference, body composition (increased fat mass and reduced fat free mass), insulin, triglycerides and HDL cholesterol. The gene discussed is INS; the disease is Hirsutism.