The RBPs with roles in ALS discovered to date include TDP-43, FUS, ATXN2, TATA-box binding protein associated factor 15 (TAF15), Ewing's sarcoma breakpoint region 1 (EWSR1), matrin 3 (MATR3), T-cell-restricted intracellular antigen-1 (TIA1), heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1), and heterogeneous nuclear ribonucleoprotein (hnRNPA2/B1). The gene discussed is MATR3; the disease is amyotrophic lateral sclerosis.