PFN1 and amyotrophic lateral sclerosis: Besides C9orf 72, SOD1, TARDBP, and FUS, Ataxin-2 (ATXN2), Optineurin (OPTN), Valosin-containing protein (VCP), Profilin 1 (PFN1), Ubiquilin 2 and Ubiquilin 4 (UBQLN2 and 4) NIMA-like kinase 1 (NEK-1), Coiled-coil-helix-coiled-coil-helix domain containing 10 (CHCHD10), Senatxin (SETX), TANK-binding kinase 1 (TBK1), Kinesin heavy chain isoform 5A (KIF5A), and other genes have been linked with ALS (52).