BRCA1 and cleft palate: Consistent with our hypothesis, the protein levels of p53 in palate tissues were much higher in Brca1 cKO and Brca2 cKO mutants than in the controls (Supplementary Figures 5A,B), suggesting that DNA damage-induced p53 stabilization may be responsible for the etiology of cleft palate in Brca1 cKO and Brca2 cKO mutants.