AKT1 and colonic neoplasm: Another study indicated that treatment of human colon tumor cell lines (HCT116 and SW620) with naringin suppressed the CRC cell viability and proliferation, and promoted apoptosis by suppressing the phosphoinositide-3 kinase (PI3K)/protein kinase-B (also known as Akt)/mammalian target of rapamycin (mTOR) signaling pathway (Chidambara Murthy et al., 2012; Cheng et al., 2020).