Taking into account previous studies on animals that have shown that chronic treatments with ACEI/ARBs could upregulate circulating ACE2 (while clinical studies had failed to demonstrate such an association), it was postulated at the beginning of the COVID-19 pandemic that treatment with ACEIs/ARBs could be harmful, could affect SARS-CoV-2 infectivity, and may alter COVID-19 disease progression by altering ACE2 expression (Esler and Esler, 2020; Fang et al., 2020). Here, ACE2 is linked to COVID-19.