TNF and Alzheimer disease: The 3 × Tg-AD mouse model shows increased levels of peripheral and CNS inflammatory markers including TNF-related apoptosis inducing ligand (TNFSF10), a potent pro-apoptotic member of the TNF superfamily, which are reverted by treatment with an anti-TNF antibody (Cantarella et al., 2015; Di Benedetto et al., 2019).