Studies aimed at investigating the link between α-Syn and immune responses in PD have suggested a direct involvement of circulating abnormal α-Syn in the dysregulated inflammatory T cell profiles observed in PD, demonstrating the potential for abnormal circulating α-Syn to stimulate cytokine production in peripheral CD4 and CD8 T cells (Sulzer et al., 2017). The gene discussed is CD8A; the disease is Parkinson disease.