Likewise, dithiopthalimide (Zhu et al., 2003; Tweedie et al., 2009) has demonstrated the ability to mitigate markers of neuroinflammation and lowered tau and amyloid accumulation as well as cognitive deficits in a 3 × Tg-AD mouse model – as evaluated under the compound name of isoindolin-1,3 dithione (Gabbita et al., 2015), without reference to its original synthesis (Zhu et al., 2003). Here, MAPT is linked to Alzheimer disease.