Key among the targets is TNF-α as a master regulator of the inflammatory process, and whose targeting in the treatment of rheumatoid arthritis and a broad number of autoimmune disorders has provided a huge improvement in the management of these illness (Feldmann et al., 1998, 2010; Feldmann and Maini, 2008; Shepard et al., 2017). This evidence concerns the gene TNF and autoimmune disease.