Specifically, in one study recently published by Escott-Price et al. (2019b), the application of a PRS to homozygous APOE-ε3 carriers achieved an AUC of 0.831 for the prediction of AD with a comparable AUC of 0.834 after excluding the variants in the APOE region in homozygous APOE-ε3 carriers. Here, APOE is linked to Alzheimer disease.