Meanwhile, a whole-exome sequencing study conducted by Patel et al. (2018) revealed the applicability of polygenic score models using exonic variants to predict AD, yielding an AUC of 0.830 for AD prediction with the inclusion of APOE genotype, age, sex, and 19 GWAS-identified SNPs, further implying the polygenic contribution of the exonic regions to the modulation of AD risk. Here, APOE is linked to Alzheimer disease.