As the ATN biomarkers in cerebrospinal fluid (CSF) are correlated with the brain pathology in AD, several studies also suggest possible correlations between PRSs and CSF biomarkers including Aβ (Sabuncu et al., 2012; Martiskainen et al., 2015; Darst et al., 2017; Cruchaga et al., 2018; Hayes et al., 2020; Li et al., 2020) and tau or p-tau (Louwersheimer et al., 2016; Darst et al., 2017; Cruchaga et al., 2018; Porter et al., 2018a; Tan et al., 2018; Altmann et al., 2020; Li et al., 2020; Reus et al., 2020). Here, MAPT is linked to Alzheimer disease.