Existing studies have shown that inflammatory response plays a vital role in the occurrence and development of CHD, T2DM, chronic obstructive pulmonary disease (COPD), chronic hepatitis, periodontitis [14], Alzheimer's disease (AD), etc. IL-6 [15, 16] has been shown to be negatively correlated with heart rate variability (HRV) in CHD women, elevated HRV is associated with parasympathetic excitation, the increased threshold of ventricular fibrillation is a protective factor, and this study reconfirms that IL-6 is a risk factor for CHD. This evidence concerns the gene IL6 and periodontitis.