Univariate analysis using clinical factors (age, family history, smoking history, initial stage of diagnosis, and endocrine responsiveness) and gene mutation status (TP53, PIK3CA, AKT1, ESR1, and MYC) demonstrated that endocrine responsiveness was the only significant factor affecting overall survival in recurrent breast cancer patients (P = 0.0059). This evidence concerns the gene AKT1 and breast cancer.