Treatment with the combination of pioglitazone (15 mg/kg/day) and metformin improved lung adenoma cancero39, reduced nitric oxide (NO), TNF-α, interleukin 1-beta (IL-1β), IL-6, and interleukin 8 (IL-8) but elevated IL-4 and interleukin10 (IL-10) levels in lipopolysaccharide stimulated astrocytes (LPS-stimulated astrocytes)40. The gene discussed is TNF; the disease is lung adenoma.