IGHE and asthma: In addition, studies have also reported improvement of tracheal responsiveness, inflammatory mediators, and total plus differential WBC12, serum cytokines and endothelin levels13, and lung pathological changes, immunoglobulin E (IgE) and eosinophil peroxidase levels in the BALF14, serum levels of total protein, in guinea pigs model of asthma as well as various cytokine gene expressions15 and T helper cells subtypes along with their cytokine gene expression16 in the splenocytes of asthmatic mice with carvacrol treatment.