In this study, we found knockdown of CB2 with siRNA significantly increased RGS17 mRNA level by 2.4 ± 0.4-fold (Fig. 8D) and infection of cochleae with adenoviral vector over expressing RGS17 led to significant reductions in CB2 expression to 0.2 ± 0.02 fold (Fig. 8E). Here, RGS17 is linked to infection.