For the TCGA CRC dataset, the OS was not significantly different between patients with TP53, KRAS, APC, PIK3CA, SMAD4, and NRAS mutations and their wild types (p = 0.58, 0.96, 0.89, 0.38, 0.19, and 0.99, respectively; Figure A9). This evidence concerns the gene SMAD4 and colorectal carcinoma.