FMR1 and fragile X-associated tremor/ataxia syndrome: Thus, the formation of the quadruplex and i-motif or i-motif conformational intermediates structures may result in aberrant bidirectional translation of FMR1 mRNA and antisense mRNA leading to RAN translation of polyG, polyA, and polyP, which are found in the ubiquitin-positive inclusion in the human brain of FXTAS patients50,52,55.