MAPT and Alzheimer disease: Although the tau propagation studies in this work were performed in a mouse model of tauopathy, the fact that the same molecular mechanisms behind the toxicity of acetylated tau on CMA and the accumulation of oligomeric acetylated tau in LE/MVB can be detected in brains from AD patients highlights CMA disruption as a previously unknown common feature of the AD brains that could also contribute to neuronal degeneration and disease progression.