HSPA8 and Alzheimer disease: The reduced levels of luminal hsc70 in the population of CMA-active lysosomes in AD (usually related to loss of stability of this chaperone in the lysosomal lumen upon loss of lysosomal acidification45) (Fig. 5a), as well as the higher presence of undegraded cargo in lysosomes isolated from AD brains (Fig. 5b), is in agreement with the reported loss of lysosomal acidification in some types of AD36,57.