Autophagic vacuoles isolated from AD brains (Fig. 5g, h, and Supplemental Fig. 5c) displayed higher content of acetylated tau (1.6 folds) than those from control brains, reflecting in part the overall cellular increase in acetylated tau and in agreement with the preferential degradation of this form of the protein by macroautophagy observed in vitro and in mouse brain sections (Fig. 1). This evidence concerns the gene MAPT and Alzheimer disease.