CD4 and neoplasm: We identified relevant changes between HM tumors vs. AA in enhancement of an immune excluded-like phenotype where T-cells (CD4 and T-helper Type 2) are rate-limiting by the over-representation of mast cells, macrophages and Tregs, thus rendering ineffective T-cells capability to infiltrate the tumor stroma (Supplementary Fig. 11c and Supplementary Data 10).