RB1 and breast cancer: Additionally, HM women harbor well-known SCNA of BC, among which gain of chromosomic regions 8q, 11q, and 17q that contain oncogenes such as MYC, CCND1 and ERBB2. Similarly, we detected losses on chromosomes 7q, 8p, 13q, 17p, containing MLL3, CSMD1, RB1 and MAP2K4 genes.