C. difficile infection (CDI) is characterized by watery stool accompanied by toxin-mediated inflammation of the bowel where primary risk factors include hospitalization, age, colonization by toxigenic C. difficile, and most importantly, antibiotic exposure where use of fluoroquinolones (FQNs), clindamycin, carbapenems, cephalosporins, and penicillins combined with beta-lactamase inhibitors (PBLs) are associated with increased CDI risk4–9. Here, LACTB is linked to clostridium difficile infection.