To test if our integrative approach can also be applied to identify novel TNBC-specific genes driven by SEs, we focused on one of the top hits, ANLN, as its high expression in breast cancer patients has been shown to be significantly correlated to recurrence, expression of proliferation genes (all 17 tested in ref. 40), as well as poor overall survival (Fig. 6a;41). The gene discussed is ANLN; the disease is breast cancer.