Gene expression from the Cancer Genoma Atlas (TCGA) showed a correlation between Timd4 transcripts and a gene signature for human cDC18, and effector CD8 T cells and better survival for patients expressing high levels of cDC1 and Timd4. In addition, a small trial showed a better response to checkpoint blockade in patients, suggesting an association between TIM4 expression and protective immune responses in human lung tumors. The gene discussed is MPPE1; the disease is cancer.