Remarkably, previous microarray analyses indicate that TIM-3 expression is also dependent on SAP in this late stage3, implying that reduced TIM-3 levels (~1.8-fold) may contribute to reduced pro-apoptotic protein induction and RICD resistance in SAP-deficient CD8+ effector T cells from XLP-1 patients. Here, SH2D1A is linked to X-linked lymphoproliferative syndrome.