The incidence of mammary tumors triggered by mammary-specific overexpressing activated ErbB2 was obviously lower in mice carrying a knock-in mutant Becn1F121A/F121A with increased autophagy, compared to Becn1WT/WT mice, and these mutant Becn1F121A/F121A mice had significant longer life span, demonstrating that ErbB2-mediated autophagy suppression facilitates breast tumorigenesis30. This evidence concerns the gene ERBB2 and breast cancer.