Through seed-sequence mimicry, multiple targets of miR-141-3p are cotargeted by miR-BART9-3p, and although several identified miRNA targets (ZEBs, YY1, and RANBP9) have previously described roles in repressing reactivation in epithelial cells, we demonstrate here that one common target of these miRNAs, FOXO3, restricts the lytic phase in BL cells. Here, RANBP9 is linked to Burkitt lymphoma.