Additionally, directly comparing cobas HIV-1/HIV-2 Qual to an alternative HIV-1 (Aptima Qual) or HIV-2 (UW HIV-2 LDT) NAT in persons with known HIV infection, the PPA and OPA were very high (>99.5% for both targets) with the one discordant result positive by cobas HIV-1/HIV-2 Qual and confirmed by alternative NAT testing, indicating a false-negative Aptima Qual result. Here, BRD2 is linked to HIV infectious disease.